@prefix dc: .
@prefix : .
@prefix ro: .
@prefix efo: .
@prefix iao: .
@prefix snap: .
@prefix j.0: .
@prefix SO: .
@prefix bfo: .
@prefix obo2: .
@prefix obo: .
@prefix rdfs: .
@prefix owl2xml: .
@prefix purl: .
@prefix owl: .
@prefix xsd: .
@prefix rdf: .
@prefix CHEBI: .
@prefix PRO: .
@prefix OBO_REL: .
@prefix oboInOwl: .
@prefix transmed: .
@prefix span: .
snap:Disposition a owl:Class .
transmed:TMO_0124 a owl:Class ;
rdfs:label "human"@en ;
rdfs:subClassOf transmed:TMO_0144 ;
owl:disjointWith transmed:TMO_0145 .
transmed:TMO_0039 a owl:Class ;
rdfs:label "genotype with copy number variation"@en ;
rdfs:subClassOf transmed:TMO_0080 ;
dc:description "A genotype of which variants with a different number of copies of a sequence identifical region exist."@en ;
oboInOwl:hasDbXref "SO:0001019"^^xsd:string .
transmed:TMO_0196 a owl:ObjectProperty ;
rdfs:label "has attribute"@en ;
owl:inverseOf transmed:TMO_0223 .
transmed:TMO_0009 a owl:Class ;
rdfs:label "medical expert role"@en ;
rdfs:subClassOf transmed:TMO_0074 ;
dc:description "An medical expert role is a role played by a human in a clinical context who is involved in the assessment or administration of treatment or its results."@en ;
oboInOwl:hasDbXref "OCRe_clinical:Clinician" .
transmed:TMO_0070 a owl:Class ;
rdfs:label "diagnostic exclusion criterion"@en ;
rdfs:subClassOf transmed:TMO_0068 ;
dc:description "A diagnostic exclusion criterion is a diagnostic criterion for consideration during a diagnosis which, if satisfied, excludes a diagnostic result."@en ;
oboInOwl:hasDbXref "IAO:0000124" .
obo2:IAO_0000136 a owl:ObjectProperty ;
owl:inverseOf transmed:TMO_0224 .
transmed:TMO_0166 a owl:Class ;
rdfs:label "ancestral allele"@en ;
rdfs:subClassOf transmed:TMO_0048 ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onProperty transmed:TMO_0079 ;
owl:someValuesFrom transmed:TMO_0048
] ;
dc:description "In a group of allelic variants in a population, the ancestral allele is the allele from which all other allelic variants are believed to have descended from during phylogeny."@en .
transmed:TMO_0040 a owl:Class ;
rdfs:label "drug-drug interaction"@en ;
rdfs:subClassOf transmed:TMO_0304 ;
dc:description "A drug-drug interaction is a drug interaction in which two drugs interact in such a way to produce an abnormal phenotypic event."@en ;
oboInOwl:hasDbXref "SNOMEDCT:404204005"^^xsd:string , "IAO:0000124" .
transmed:TMO_0221 a owl:Class ;
rdfs:label "diagnostic role "@en ;
rdfs:subClassOf snap:Role ;
owl:disjointWith obo2:IAO_0000442 , transmed:TMO_0074 , transmed:TMO_0073 , transmed:TMO_0006 .
transmed:TMO_0136 a owl:Class ;
rdfs:label "medical finding"@en ;
rdfs:subClassOf transmed:TMO_0135 .
transmed:TMO_0010 a owl:Class ;
rdfs:label "biomedical measure"@en ;
rdfs:subClassOf transmed:TMO_0093 ;
dc:description "A biomedical measure is an information content entity that describes or is a measure of biomedically relevant entities."@en .
transmed:TMO_0106 a owl:Class ;
rdfs:label "physical description"@en ;
rdfs:subClassOf transmed:TMO_0089 .
transmed:TMO_0082 a owl:Class ;
rdfs:label "gene variant"@en ;
rdfs:subClassOf transmed:TMO_0109 ;
dc:description "A gene variant is a variant of another gene based on some difference in sequence (composition and connectivity)"@en .
transmed:TMO_0178 a owl:Class ;
rdfs:label "age"@en ;
rdfs:subClassOf transmed:TMO_0147 .
transmed:TMO_0052 a owl:Class ;
rdfs:label "biomarker"@en ;
rdfs:subClassOf transmed:TMO_0019 ;
dc:description "A biomarker is a characteristic of a material entity that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a therapeutic intervention."@en ;
oboInOwl:hasDbXref "MSH:D054316"^^xsd:string , "NCIt:Biomarker"^^xsd:string , "UMLS:C1955886"^^xsd:string , "IAO:0000121" .
transmed:TMO_0148 a owl:Class ;
rdfs:label "time elapsed"@en ;
rdfs:subClassOf transmed:TMO_0147 .
transmed:TMO_0022 a owl:Class ;
rdfs:label "sign"@en ;
rdfs:subClassOf transmed:TMO_0019 ;
obo2:IAO_0000119 "Richard Scheuermann, Werner Ceusters, Barry Smith in \"Toward an Ontological Treatment of Disease and Diagnosis\"" ;
dc:description "A quality of a patient, a material entity that is part of a patient, or a processual entity that a patient participates in, any one of which is observed in a physical examination and is deemed by the clinician to be of clinical significance."@en ;
oboInOwl:hasDbXref "NCIt:Sign"^^xsd:string , "SNOMEDCT:72670004"^^xsd:string , "UMLS:C0311392"^^xsd:string .
transmed:TMO_0203 a owl:NamedIndividual , transmed:TMO_0140 ;
rdfs:label "Yoruba in Ibadan, Nigeria"@en ;
dc:description "A particular community in Ibadan, Nigeria, with individuals who identified themselves as having four Yoruba grandparents. The genetic characteristics of this population were described by the HapMap project and are used as a reference for other genetic studies."@en ;
transmed:TMO_0199 "YRI"^^xsd:string .
transmed:TMO_0118 a owl:Class ;
rdfs:label "indicator"@en ;
rdfs:subClassOf transmed:TMO_0109 ;
dc:description "An indicator is an entity for which its observation/detection is used in some objective."@en .
transmed:TMO_0094 a owl:Class ;
rdfs:label "quantity"@en ;
rdfs:subClassOf obo2:IAO_0000030 ;
dc:description "A quantity is a quantitative measure of some feature."@en .
snap:Role a owl:Class .
obo2:IAO_0000300 rdfs:subClassOf transmed:TMO_0089 .
transmed:TMO_0064 a owl:Class ;
rdfs:label "active ingredient role"@en ;
rdfs:subClassOf transmed:TMO_0062 ;
dc:description "An active ingredient role is a role played by a chemical substance which has the disposition to treat a certain disease and is part of a pharmaceutical formulation."@en .
obo2:IAO_0000004 rdfs:subPropertyOf transmed:TMO_0185 .
transmed:TMO_0034 a owl:Class ;
rdfs:label "molecular entity"@en ;
rdfs:subClassOf snap:MaterialEntity ;
dc:description "Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity."@en ;
oboInOwl:hasDbXref "CHEBI:23367"^^xsd:string , "GRO:MolecularEntity"^^xsd:string .
transmed:TMO_0215 a owl:Class ;
rdfs:comment "A DNA region is a part of a DNA molecule that is made up of a continous chain of deoxyribonucleotide residues."^^xsd:string ;
rdfs:label "DNA region"@en ;
rdfs:subClassOf transmed:TMO_0228 .
transmed:TMO_0191 a owl:Class ;
rdfs:label "dose in milligram per week"@en ;
rdfs:subClassOf transmed:TMO_0190 ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onProperty transmed:TMO_0185 ;
owl:someValuesFrom xsd:double
] ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onProperty transmed:TMO_0186 ;
owl:someValuesFrom transmed:TMO_0189
] .
transmed:TMO_0004 a owl:Class ;
rdfs:label "absent phenotype"@en ;
rdfs:subClassOf transmed:TMO_0019 ;
dc:description "An absent phenotype is a phenotype that represents the notable absence of a characteristic."@en .
transmed:TMO_0161 a owl:Class ;
rdfs:label "snp identifier"@en ;
rdfs:subClassOf transmed:TMO_0159 .
transmed:TMO_0076 a owl:Class ;
rdfs:label "assay"@en ;
rdfs:subClassOf transmed:TMO_0075 ;
dc:description "An assay is a planned process with the objective to obtain information about a material entity."@en ;
oboInOwl:hasDbXref "MSH:Q000032"^^xsd:string , "OBI:0000070" , "Galen:Assay"^^xsd:string , "cto_asyont:Assay"^^xsd:string , "PATO:0000003"^^xsd:string , "SNOMEDCT:272392009"^^xsd:string , "EFO:0001455"^^xsd:string , "NCIt:Assay"^^xsd:string , "UMLS:C1510438"^^xsd:string , "BIRNLex:11025"^^xsd:string .
transmed:TMO_0131 a owl:Class ;
rdfs:label "DNA sequence"@en ;
rdfs:subClassOf transmed:TMO_0130 ;
dc:description "a DNA sequence is a sequence of characters that represents the composition and connectivity of a a DNA molecule."@en ;
owl:disjointWith transmed:TMO_0132 .
transmed:TMO_0046 a owl:Class ;
rdfs:label "arm of clinical study"@en ;
rdfs:subClassOf transmed:TMO_0045 ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onProperty obo2:OBI_0000316 ;
owl:someValuesFrom transmed:TMO_0060
] ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onProperty ro:has_proper_part ;
owl:someValuesFrom transmed:TMO_0124
] ;
dc:description "An arm of clinical study is a population that participates in a clinical trial and is subject to some intervention."@en ;
oboInOwl:hasDbXref "linkedct:trial_arm_group" , "IAO:0000120" ;
owl:disjointWith transmed:TMO_0139 , transmed:TMO_0036 .
transmed:TMO_0227 a owl:Class ;
rdfs:label "genotype with multiple nucleotide polymorphism"@en ;
rdfs:subClassOf transmed:TMO_0080 ;
dc:description "A genotype with a multiple-nucleotide polymorphism (MNP). An MNP is a variation of several adjacent nucleotides in the genomes of members of a species. For a variation to be considered an MNP, it must occur in at least 1% of the population."@en .
transmed:TMO_0101 a owl:Class ;
rdfs:label "ranged numerical quantity"@en ;
rdfs:subClassOf transmed:TMO_0120 .
transmed:TMO_0016 a owl:Class ;
rdfs:label "clinical protocol"@en ;
rdfs:subClassOf obo2:IAO_0000033 ;
dc:description "A clinical protocol is a directive information entity about the objective(s), design, methodology, statistical considerations, and organization of a clinical procedure."@en ;
oboInOwl:hasDbXref "IAO:0000124" .
ro:has_proper_part a owl:ObjectProperty .
transmed:TMO_0173 a owl:Class ;
rdfs:label "insertion"@en ;
rdfs:subClassOf transmed:TMO_0109 .
transmed:TMO_0088 a owl:Class ;
rdfs:label "female"@en ;
rdfs:subClassOf transmed:TMO_0086 ;
dc:description "Female is a sex quality for which sex organs contain only female gametes"@en .
obo2:IAO_0000028 rdfs:subClassOf transmed:TMO_0137 .
ro:integral_part_of rdfs:subPropertyOf
ro:proper_part_of .
transmed:TMO_0143 a owl:Class ;
rdfs:label "patient record"@en ;
rdfs:subClassOf transmed:TMO_0135 .
transmed:TMO_0058 a owl:Class ;
rdfs:label "syndrome"@en ;
rdfs:subClassOf transmed:TMO_0084 ;
dc:description "A syndrome is a group of signs and symptoms that characterize a particular abnormality."@en ;
oboInOwl:hasDbXref "ACGT:Syndrome"^^xsd:string , "EFO:0000428"^^xsd:string , "MSH:D013577"^^xsd:string , "UMLS:C0039082"^^xsd:string , "EFO:0000716"^^xsd:string , "NCIt:Syndrome"^^xsd:string , "DOID:225"^^xsd:string .
transmed:TMO_0113 a owl:Class ;
rdfs:label "temporal functional quantity"@en ;
rdfs:subClassOf transmed:TMO_0100 .
transmed:TMO_0028 a owl:Class ;
rdfs:label "market"@en ;
rdfs:subClassOf transmed:TMO_0025 .
OBO_REL:bearer_of rdfs:subPropertyOf transmed:TMO_0196 .
transmed:TMO_0209 a owl:NamedIndividual , transmed:TMO_0140 ;
rdfs:label "Maasai in Kinyawa, Kenya"@en ;
dc:description "The genetic characteristics of this population were described by the HapMap project and are used as a reference for other genetic studies."@en ;
transmed:TMO_0199 "MKK"^^xsd:string .
transmed:TMO_0185 a owl:DatatypeProperty , owl:FunctionalProperty ;
rdfs:label "has value"@en .
obo2:IAO_0000306 rdfs:subClassOf transmed:TMO_0089 .
transmed:TMO_0155 a owl:Class ;
rdfs:comment "A nucleic acid region is a part of a nucleic acid that is made up of a continous chain of nucleotide residues."@en ;
rdfs:label "nucleic acid region"@en ;
rdfs:subClassOf transmed:TMO_0109 ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onProperty ro:part_of ;
owl:someValuesFrom transmed:TMO_0167
] .
dc:creator a owl:AnnotationProperty .
transmed:TMO_0210 a owl:NamedIndividual , transmed:TMO_0140 ;
rdfs:label "Toscani in Italia"@en ;
dc:description "The genetic characteristics of this population were described by the HapMap project and are used as a reference for other genetic studies."@en ;
transmed:TMO_0199 "TSI"^^xsd:string .
transmed:TMO_0125 a owl:Class ;
rdfs:label "nucleotide sequence position"@en ;
rdfs:subClassOf transmed:TMO_0119 ;
dc:description "A nucleotide sequence position indicates the position of a nucleotide residue in relation to the start of the nucleic acid."@en .
transmed:TMO_0197 a owl:Class ;
rdfs:label "pharmgkb subject identifier"@en ;
rdfs:subClassOf transmed:TMO_0158 .
transmed:TMO_0071 a owl:Class ;
rdfs:label "pharmaceutical ingredient"@en ;
rdfs:subClassOf transmed:TMO_0063 ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onProperty ro:part_of ;
owl:someValuesFrom transmed:TMO_0001
] ;
dc:description "A pharmaceutical ingredient is a chemical substance that is part of a formulated pharmaceutical that bears a pharmaceutical ingredient role."@en ;
oboInOwl:hasDbXref "dailymed:ingredients" ;
owl:equivalentClass [ a owl:Class ;
owl:intersectionOf ( transmed:TMO_0063 [ a owl:Restriction ;
owl:onProperty ro:part_of ;
owl:someValuesFrom transmed:TMO_0001
] )
] .
transmed:TMO_0167 a owl:Class ;
rdfs:label "nucleic acid"@en ;
rdfs:subClassOf transmed:TMO_0109 .
transmed:TMO_0041 a owl:Class ;
rdfs:label "disease progression"@en ;
rdfs:subClassOf span:ProcessualEntity ;
oboInOwl:hasDbXref "IAO:0000124" , "OBI:0000354"^^xsd:string , "NCIt:Disease_Progression"^^xsd:string , "MSH:D018450"^^xsd:string , "UMLS:C0242656"^^xsd:string , "NDFRT:C7812"^^xsd:string .
transmed:TMO_0222 a owl:ObjectProperty ;
rdfs:label "provides supporting evidence for "@en ;
rdfs:subPropertyOf obo2:IAO_0000136 .
transmed:TMO_0137 a owl:Class ;
rdfs:label "identifier"@en ;
rdfs:subClassOf obo2:IAO_0000030 ;
dc:description "An identifier is an information content entity which consists of one or more symbols in order to identify some entity."@en .
transmed:TMO_0011 a owl:Class ;
rdfs:comment "Examples: connection table, fragment, pharmacophore." ;
rdfs:label "molecular structure description"@en ;
rdfs:subClassOf transmed:TMO_0106 ;
dc:description "A molecular structure description is a description of a molecule in terms of its composition and connectivity."@en .
transmed:TMO_0107 a owl:Class ;
rdfs:label "3D molecular structure"@en ;
rdfs:subClassOf transmed:TMO_0011 .
transmed:TMO_0083 a owl:Class ;
rdfs:label "ethnicity"@en ;
rdfs:subClassOf transmed:TMO_0084 ;
dc:description "Ethinicity is the quality of an organism that describes membership in a social group based on a common heritage."@en .
transmed:TMO_0179 a owl:Class ;
rdfs:label "age in years"@en ;
rdfs:subClassOf transmed:TMO_0178 ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onProperty transmed:TMO_0186 ;
owl:someValuesFrom transmed:TMO_0184
] ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onProperty transmed:TMO_0185 ;
owl:someValuesFrom [ a rdfs:Datatype ;
owl:onDatatype xsd:int ;
owl:withRestrictions ( [ xsd:minInclusive
0 ] [ xsd:maxInclusive 9 ] )
]
] .
transmed:TMO_0053 a owl:Class ;
rdfs:label "comparative effectiveness"@en ;
rdfs:subClassOf transmed:TMO_0092 ;
dc:description "Comparative effectiveness is a drug measure that provides information about which treatment works best, for whom, and under what circumstances."@en ;
oboInOwl:hasDbXref "IAO:0000121" .
obo2:IAO_0000119 a owl:AnnotationProperty .
dc:title a owl:AnnotationProperty .
transmed:TMO_0149 a owl:Class ;
rdfs:label "mass value"@en ;
rdfs:subClassOf transmed:TMO_0146 ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onProperty transmed:TMO_0185 ;
owl:someValuesFrom xsd:double
] .
transmed:TMO_0023 a owl:Class ;
rdfs:label "symptom"@en ;
rdfs:subClassOf transmed:TMO_0019 ;
obo2:IAO_0000119 "Richard Scheuermann, Werner Ceusters, Barry Smith in \"Toward an Ontological Treatment of Disease and Diagnosis\"" ;
dc:description "A quality of a patient that is observed by the patient or a processual entity experienced by the patient, either of which is hypothesized by the patient to be a realization of a disease."@en ;
oboInOwl:hasDbXref "ACGT:Symptom"^^xsd:string , "CPR:symptom"^^xsd:string , "NCIt:Symptom"^^xsd:string , "UMLS:C1457887"^^xsd:string .
transmed:TMO_0204 a owl:NamedIndividual , transmed:TMO_0140 ;
rdfs:label "Population with african ancestry in Southwest USA"@en ;
dc:description "The genetic characteristics of this population were described by the HapMap project and are used as a reference for other genetic studies."@en ;
transmed:TMO_0199 "ASW"^^xsd:string .
transmed:TMO_0119 a owl:Class ;
rdfs:label "sequence position"@en ;
rdfs:subClassOf transmed:TMO_0159 ;
dc:description "A sequence position is a identifier for an item in a sequence of items and whose numeric value relates to the position of the item from the start of the sequence."@en .
transmed:TMO_0180 a owl:Class ;
rdfs:label "weight in kilograms"@en ;
rdfs:subClassOf transmed:TMO_0149 ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onProperty transmed:TMO_0186 ;
owl:someValuesFrom transmed:TMO_0183
] ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onProperty transmed:TMO_0185 ;
owl:someValuesFrom xsd:double
] .
transmed:TMO_0095 a owl:Class ;
rdfs:label "toxic"@en ;
rdfs:subClassOf transmed:TMO_0056 .
transmed:TMO_0150 a owl:Class ;
rdfs:label "length value"@en ;
rdfs:subClassOf transmed:TMO_0146 ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onProperty transmed:TMO_0185 ;
owl:someValuesFrom xsd:double
] .
transmed:TMO_0065 a owl:Class ;
rdfs:label "inactive ingredient role"@en ;
rdfs:subClassOf transmed:TMO_0062 ;
dc:description "An inactive ingredient role is a role played by a chemical substance which is part of a pharmaceutical formulation but does not have the disposition to treat a certain disease."@en .
transmed:TMO_0120 a owl:Class ;
rdfs:label "numerical quantity selected from a continuous variable"@en ;
rdfs:subClassOf transmed:TMO_0099 .
transmed:TMO_0035 a owl:Class ;
rdfs:label "protein"@en ;
rdfs:subClassOf transmed:TMO_0034 ;
dc:description "A biological macromolecule that is composed of amino acids linked in a linear sequence (a polypeptide chain)."@en ;
oboInOwl:hasDbXref "GRO:Protein"^^xsd:string , "ODGI:Protein"^^xsd:string , "SNOMEDCT:88878007"^^xsd:string , "ACGT:Protein"^^xsd:string , "CHEBI:36080"^^xsd:string , "BIRNLex:23"^^xsd:string , "GO:0003675"^^xsd:string , "SO:0000358"^^xsd:string , "UMLS:C0033684"^^xsd:string , "Galen:Protein"^^xsd:string , "NCIt:Protein"^^xsd:string , "PRO:000000001"^^xsd:string , "FMA:Protein"^^xsd:string ;
owl:disjointWith transmed:TMO_0167 , transmed:TMO_0220 , transmed:TMO_0168 .
transmed:TMO_0216 a owl:SymmetricProperty ;
rdfs:label "is variant of"@en .
transmed:TMO_0192 a owl:Class ;
rdfs:label "ratio"@en ;
rdfs:subClassOf transmed:TMO_0100 .
transmed:TMO_0005 a owl:Class ;
rdfs:label "genetic description"@en ;
rdfs:subClassOf transmed:TMO_0089 ;
dc:description "A genetic description is a description of the genetic composition of some entity."@en .
obo2:IAO_0000313 a owl:Class ;
owl:equivalentClass transmed:TMO_0012 .
transmed:TMO_0162 a owl:Class ;
rdfs:label "ncbi reference snp identifier"@en ;
rdfs:subClassOf transmed:TMO_0161 ;
owl:disjointWith transmed:TMO_0163 .
transmed:TMO_0077 a owl:Class ;
rdfs:label "clinical trial criterion"@en ;
rdfs:subClassOf transmed:TMO_0151 ;
dc:description "A clinical trial criterion is a directive information entity which, if satisfied, contributes to the inclusion or exclusion of candidate patients."@en .
transmed:TMO_0132 a owl:Class ;
rdfs:label "RNA sequence"@en ;
rdfs:subClassOf transmed:TMO_0130 .
transmed:TMO_0047 a owl:Class ;
rdfs:label "disease"@en ;
rdfs:subClassOf transmed:TMO_0084 ;
obo2:IAO_0000119 "Richard Scheuermann, Werner Ceusters, Barry Smith in \"Toward an Ontological Treatment of Disease and Diagnosis\"" ;
dc:description "A quality of an organism which predisposes it to undergo pathological processes because of one or more disorders in that organism."@en ;
oboInOwl:hasDbXref "ACGT:Disease"^^xsd:string , "LNC:LP21006-9"^^xsd:string , "DOID:4"^^xsd:string , "NDFRT:C2140"^^xsd:string , "GRO:Disease"^^xsd:string , "diseasome:diseases" , "pharmgkb:Disease" , "UMLS:C0012634"^^xsd:string , "OBI:0000155"^^xsd:string , "BIRNLex:11013"^^xsd:string , "linkedct:condition" , "MSH:D004194"^^xsd:string , "NCIt:Disease_or_Disorder"^^xsd:string .
transmed:tmo a owl:Ontology ;
rdfs:comment "Further information can be found in the publication \"The Translational Medicine Ontology and Knowledge Base: driving personalized medicine by bridging the gap between bench and bedside\", published in the Journal of Biomedical Semantics: http://www.jbiomedsem.com/content/2/S2/S1"^^xsd:string ;
dc:creator "Elgar Pichler" , "Matthias Samwald" , "Susie Stephens" , "M. Scott Marshall"^^xsd:string , "Trish Whetzel" , "Julia Kozlovsky" , "Joanne Luciano" , "Michel Dumontier" , "Christi Denney" , "Colin Batchelor" ;
dc:description "The Translational Medicine Ontology (TMO) is a high-level, patient-centric ontology that extends existing domain ontologies to integrate data across aspects of drug discovery and clinical practice. The ontology has been developed by participants in the World Wide Web Consortium’s Semantic Web for Health Care and Life Sciences Interest Group."@en ;
dc:publisher "W3C Health Care and Life Sciences Interest Group" ;
dc:rights "Creative Commons - By Attribution" ;
dc:subject "ontology, translational medicine, personalized medicine, life sciences, health care"^^xsd:string ;
dc:title "Translational Medicine Ontology" ;
j.0:imports ;
owl:imports ;
owl:versionInfo "1.0.2"^^xsd:string .
transmed:TMO_0228 a owl:Class ;
rdfs:comment "A part of a molecular entity or a set of molecular entities. It can be made up of several non-connected sub-parts, potentially on separate molecular entities."^^xsd:string ;
rdfs:label "molecular entity part"@en ;
rdfs:subClassOf snap:MaterialEntity ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onProperty ro:part_of ;
owl:someValuesFrom transmed:TMO_0034
] .
transmed:TMO_0102 a owl:Class ;
rdfs:label "scale numerical value"@en ;
rdfs:subClassOf transmed:TMO_0101 .
transmed:TMO_0017 a owl:Class ;
rdfs:label "evidence"@en ;
rdfs:subClassOf transmed:TMO_0109 ;
dc:description "Evidence is a group of indicators that are relevant in some decision-making process."@en ;
oboInOwl:hasDbXref "NCIt:Evidence"^^xsd:string , "UMLS:C0332120"^^xsd:string , "IAO:0000123" .
transmed:TMO_0174 a owl:Class ;
rdfs:label "deletion"@en ;
rdfs:subClassOf transmed:TMO_0109 .
transmed:TMO_0089 a owl:Class ;
rdfs:label "description"@en ;
rdfs:subClassOf obo2:IAO_0000030 .
transmed:TMO_0144 a owl:Class ;
rdfs:label "organism"@en ;
rdfs:subClassOf snap:MaterialEntity .
transmed:TMO_0059 a owl:Class ;
rdfs:label "hypothesis"@en ;
rdfs:subClassOf transmed:TMO_0089 ;
dc:description "A hypothesis is an information content entity that describes a possible correlation between two or more variables."@en ;
oboInOwl:hasDbXref "NCIt:Hypothesis"^^xsd:string , "OBI:0000074"^^xsd:string , "UMLS:C1512571"^^xsd:string .
transmed:TMO_0114 a owl:Class ;
rdfs:label "pharmacokinetic measure"@en ;
rdfs:subClassOf transmed:TMO_0100 .
transmed:TMO_0029 a owl:Class ;
rdfs:label "study"@en ;
rdfs:subClassOf transmed:TMO_0075 ;
dc:description "A study is a planned process that consists of planning, study execution, documentation and the production of conclusion(s)."@en ;
oboInOwl:hasDbXref "IAO:0000121" , "LNC:LP74341-6"^^xsd:string , "NCIt:Study"^^xsd:string , "UMLS:C0947630"^^xsd:string , "OCRe_research:Study"^^xsd:string , "OBI:0000471" , "SNOMEDCT:224699009"^^xsd:string .
transmed:TMO_0090 a owl:Class ;
rdfs:label "process description"@en ;
rdfs:subClassOf transmed:TMO_0089 .
obo2:IAO_0000030 a owl:Class ;
owl:disjointWith transmed:TMO_0164 .
transmed:TMO_0186 a owl:ObjectProperty , owl:FunctionalProperty ;
rdfs:domain transmed:TMO_0094 ;
rdfs:label "has unit"@en ;
rdfs:range transmed:TMO_0104 .
transmed:TMO_0060 a owl:Class ;
rdfs:label "clinical subject role"@en ;
rdfs:subClassOf transmed:TMO_0006 ;
dc:description "A clinical subject role is the role played by an organism who is the subject of a clinical procedure or assessment."@en ;
oboInOwl:hasDbXref "OCRe_clinical:Subject" .
transmed:TMO_0156 a owl:Class ;
rdfs:label "dsDNA"@en ;
rdfs:subClassOf transmed:TMO_0168 .
transmed:TMO_0030 a owl:Class ;
rdfs:label "intervention"@en ;
rdfs:subClassOf transmed:TMO_0029 ;
dc:description "An intervention is a study in which a substance is administered to a subject or group of subjects."@en ;
oboInOwl:hasDbXref "NCIt:Intervention"^^xsd:string , "OCRe_research:Intervention"^^xsd:string , "linkedct:intervention" , "IAO:0000121" .
transmed:TMO_0211 a transmed:TMO_0141 ;
rdfs:label "July 2003 human reference sequence (NCBI Build 34)"@en .
transmed:TMO_0126 a owl:Class ;
rdfs:label "deoxyribonucleotide sequence position"@en ;
rdfs:subClassOf transmed:TMO_0125 ;
dc:description "A dexoyribonucleotide sequence position is an ordinal number which reflects the position of a deoxyribonucleotide in relation to the first deoxyribonucleotide of the same deoxyribonucleic acid (DNA)."@en .
transmed:TMO_0000 a owl:Class ;
rdfs:label "active ingredient"@en ;
rdfs:subClassOf transmed:TMO_0071 ;
dc:description "An active ingredient is a pharmaceutical ingredient that has the disposition to treat a certain disease."@en ;
oboInOwl:hasDbXref "HL7V3.0:ACTI"^^xsd:string ;
owl:equivalentClass [ a owl:Class ;
owl:intersectionOf ( transmed:TMO_0071 [ a owl:Restriction ;
owl:onProperty obo2:OBI_0000316 ;
owl:someValuesFrom transmed:TMO_0064
] [ a owl:Restriction ;
owl:onProperty ro:part_of ;
owl:someValuesFrom transmed:TMO_0001
] )
] .
transmed:TMO_0198 a owl:Class ;
rdfs:label "race"@en ;
rdfs:subClassOf transmed:TMO_0084 .
transmed:TMO_0072 a owl:Class ;
rdfs:label "molecular target role"@en ;
rdfs:subClassOf transmed:TMO_0073 ;
dc:description "A molecular target role is a role played by a chemical entity in which it is a specific target of an intervention that aims to change it behavior."@en .
obo2:IAO_0000404 rdfs:subPropertyOf transmed:TMO_0185 .
transmed:TMO_0168 a owl:Class ;
rdfs:label "molecular complex"@en ;
rdfs:subClassOf transmed:TMO_0034 ;
owl:disjointWith transmed:TMO_0220 , transmed:TMO_0035 .
transmed:TMO_0042 a owl:Class ;
rdfs:label "mechanism of action"@en ;
rdfs:subClassOf transmed:TMO_0090 ;
dc:description "The mechanism of action is a description of processes and behaviour of a biologically active molecule in its administration into a living system."@en ;
oboInOwl:hasDbXref "NCIt:Mechanism_of_Action"^^xsd:string .
transmed:TMO_0223 rdfs:label "attribute of "@en .
transmed:TMO_0138 a owl:Class ;
rdfs:label "genomic sequence"@en ;
rdfs:subClassOf transmed:TMO_0128 ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onProperty ro:has_part ;
owl:someValuesFrom transmed:TMO_0130
] ;
dc:description "A genomic sequence is the collection of sequences that make up an individual's genetic matter."@en .
transmed:TMO_0012 a owl:Class ;
rdfs:label "patent"@en ;
rdfs:subClassOf obo2:IAO_0000310 ;
obo2:IAO_0000119 "American Heritage(R) Stedman's Medical Dictionary" ;
dc:description "A patent is an information entity granted by a patent office which confers upon the patenter the sole right to make, use and sell an invention for a set period of time."@en ;
oboInOwl:hasDbXref "BIRNLex:2364"^^xsd:string , "Galen:patent"^^xsd:string , "MSH:D020490"^^xsd:string , "IAO:0000313"^^xsd:string , "BRO:Patent"^^xsd:string .
transmed:TMO_0108 a owl:Class ;
rdfs:label "genetic variant"@en ;
rdfs:subClassOf transmed:TMO_0109 .
transmed:TMO_0084 a owl:Class ;
rdfs:label "organismal quality"@en ;
rdfs:subClassOf snap:Quality .
transmed:TMO_0054 a owl:Class ;
rdfs:label "lifestyle"@en ;
rdfs:subClassOf transmed:TMO_0097 ;
dc:description "Lifestyle is a description about an individual`s manner of living."@en ;
oboInOwl:hasDbXref "SNOMEDCT:366925008"^^xsd:string , "NCIt:Lifestyle"^^xsd:string , "SNOMEDCT:134436002"^^xsd:string , "IAO:0000121" , "MSH:D008019"^^xsd:string , "SNOMEDCT:367150003"^^xsd:string , "UMLS:C0023676"^^xsd:string .
transmed:TMO_0024 a owl:Class ;
rdfs:label "medical measure"@en ;
rdfs:subClassOf transmed:TMO_0010 ;
dc:description "A medical measure is a measure that describes or is a measure of medically relevant entities."@en .
transmed:TMO_0205 a owl:NamedIndividual , transmed:TMO_0140 ;
rdfs:label "Chinese in Metropolitan Denver, Colorado"@en ;
dc:description "The genetic characteristics of this population were described by the HapMap project and are used as a reference for other genetic studies."@en ;
transmed:TMO_0199 "CHD"^^xsd:string .
transmed:TMO_0181 a owl:Class ;
rdfs:label "height in centimeters"@en ;
rdfs:subClassOf transmed:TMO_0150 ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onProperty transmed:TMO_0185 ;
owl:someValuesFrom xsd:double
] ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onProperty transmed:TMO_0186 ;
owl:someValuesFrom transmed:TMO_0182
] .
transmed:TMO_0096 a owl:Class ;
rdfs:label "non toxic"@en ;
rdfs:subClassOf transmed:TMO_0056 .
obo2:IAO_0000302 rdfs:subClassOf obo2:IAO_0000009 .
transmed:TMO_0151 a owl:Class ;
rdfs:label "criterion"@en ;
rdfs:subClassOf obo2:IAO_0000033 .
transmed:TMO_0066 a owl:Class ;
rdfs:label "molecular target"@en ;
rdfs:subClassOf transmed:TMO_0034 ;
dc:description "A molecular target is a molecular entity that is the target of a transformation process."@en ;
oboInOwl:hasDbXref "drugbank:targets" ;
owl:equivalentClass [ a owl:Class ;
owl:intersectionOf ( transmed:TMO_0034 [ a owl:Restriction ;
owl:onProperty obo2:OBI_0000316 ;
owl:someValuesFrom transmed:TMO_0072
] )
] .
transmed:TMO_0121 a owl:Class ;
rdfs:label "numerical quantity selected from a discrete variable"@en ;
rdfs:subClassOf transmed:TMO_0099 .
transmed:TMO_0036 a owl:Class ;
rdfs:label "cell line"@en ;
rdfs:subClassOf transmed:TMO_0045 ;
dc:description "A cell line is a material entity that consists of a population of cells cultured in vitro that are descended through one or more generations (and possible sub-cultures) from a single primary culture which was originally derived from part of an organism."@en ;
oboInOwl:hasDbXref "EFO:0000322"^^xsd:string , "UMLS:C0007600"^^xsd:string , "MSH:D002460"^^xsd:string , "NCIt:Cell_Line"^^xsd:string , "BIRNLex:11036"^^xsd:string ;
owl:disjointWith transmed:TMO_0139 , transmed:TMO_0046 .
transmed:TMO_0217 a owl:Class ;
rdfs:label "genetic status "@en ;
rdfs:subClassOf transmed:TMO_0109 .
ro:has_integral_part rdfs:subPropertyOf
ro:has_proper_part .
transmed:TMO_0193 a owl:Class ;
rdfs:label "International Normalized Ratio on the Therapeutic Dose of Warfarin"@en ;
rdfs:subClassOf transmed:TMO_0192 .
transmed:TMO_0006 a owl:Class ;
rdfs:label "subject role"@en ;
rdfs:subClassOf snap:Role ;
dc:description "A role played by a material entity it being the subject of a study."@en ;
oboInOwl:hasDbXref "NCIt:Target"^^xsd:string , "UMLS:C1521840"^^xsd:string ;
owl:disjointWith transmed:TMO_0221 , obo2:IAO_0000442 , transmed:TMO_0074 , transmed:TMO_0073 .
transmed:TMO_0163 a owl:Class ;
rdfs:label "ncbi submitter snp identifier"@en ;
rdfs:subClassOf transmed:TMO_0161 .
transmed:TMO_0078 a owl:Class ;
rdfs:label "enzyme"@en ;
rdfs:subClassOf transmed:TMO_0035 ;
dc:description "An enzyme is a protein that catalyzes (increases the rate of) a chemical reaction."@en ;
oboInOwl:hasDbXref "drugbank:enzymes" .
transmed:TMO_0133 a owl:Class ;
rdfs:label "single letter amino acid sequence"@en ;
rdfs:subClassOf transmed:TMO_0129 .
transmed:TMO_0048 a owl:Class ;
rdfs:label "allele"@en ;
rdfs:subClassOf transmed:TMO_0172 ;
dc:description "An allele is a specific variant of a gene."@en ;
oboInOwl:hasDbXref "SO:0001023" ;
owl:equivalentClass [ a owl:Class ;
owl:intersectionOf ( [ a owl:Restriction ;
owl:onProperty transmed:TMO_0216 ;
owl:someValuesFrom transmed:TMO_0037
] transmed:TMO_0215 )
] .
transmed:TMO_0229 a owl:Class ;
rdfs:label "genotype with allele "@en ;
rdfs:subClassOf transmed:TMO_0080 ;
dc:description "A genotype containing one matching allele on each chromosome (e.g., CYP2C9*1/*3)"@en .
transmed:TMO_0103 a owl:Class ;
rdfs:label "enumerated numerical quantity"@en ;
rdfs:subClassOf transmed:TMO_0121 ;
dc:description "An enumerated numerical quantity is a numerical quantity selected from a discrete set of quantities."@en .
transmed:TMO_0018 a owl:Class ;
rdfs:label "environmental description"@en ;
rdfs:subClassOf transmed:TMO_0089 ;
dc:description "An environmental description is a description concerning some aspect of a physical environment."@en ;
oboInOwl:hasDbXref "IAO:0000123" .
transmed:TMO_0175 a owl:Class ;
rdfs:label "invariant nucleic acid region"@en ;
rdfs:subClassOf transmed:TMO_0109 .
transmed:TMO_0145 a owl:Class ;
rdfs:label "mouse"@en ;
rdfs:subClassOf transmed:TMO_0144 ;
owl:disjointWith transmed:TMO_0124 .
transmed:TMO_0200 a owl:NamedIndividual , transmed:TMO_0140 ;
rdfs:label "CEPH (Utah residents with ancestry from northern and western Europe)"@en ;
dc:description "A population of individuals living in Utah with ancestry from northern and western Europe. The genetic characteristics of this population were described by the HapMap project and are used as a reference for other genetic studies."@en ;
transmed:TMO_0199 "CEU"^^xsd:string .
transmed:TMO_0115 a owl:Class ;
rdfs:label "pharmacodynamic measure"@en ;
rdfs:subClassOf transmed:TMO_0100 .
transmed:TMO_0091 a owl:Class ;
rdfs:label "temporal quality"@en ;
rdfs:subClassOf transmed:TMO_0109 .
oboInOwl:hasDbXref a owl:AnnotationProperty .
transmed:TMO_0061 a owl:Class ;
rdfs:label "side effect"@en ;
rdfs:subClassOf span:ProcessualEntity ;
dc:description "A side effect is an effect of an intervention, whether therapeutic or adverse, that is secondary to the intended effect of the intervention."@en ;
oboInOwl:hasDbXref "NCIt:Side_Effect"^^xsd:string .
obo2:IAO_0000308 rdfs:subClassOf transmed:TMO_0089 .
transmed:TMO_0157 a owl:Class ;
rdfs:label "chromosome number"@en ;
rdfs:subClassOf transmed:TMO_0158 ;
dc:description "A chromosome number is an identifier for a chromosome that identifies it from a collection of chromosomes for a given organism."@en .
transmed:TMO_0031 a owl:Class ;
rdfs:label "diagnosis"@en ;
rdfs:subClassOf transmed:TMO_0029 ;
obo2:IAO_0000119 "NCI thesaurus" ;
dc:description "A diagnosis is a study composed of investigation, analysis and recognition of the presence and nature of disease, condition, or injury from expressed signs and symptoms; also, the scientific determination of any kind; the concise results of such an investigation."@en ;
oboInOwl:hasDbXref "Galen:Diagnosis"^^xsd:string , "ACGT:Diagnosis"^^xsd:string , "OBI:0000075"^^xsd:string , "OCRe_clinical:Diagnosis"^^xsd:string , "MSH:D003933"^^xsd:string , "FHHO:Diagnosis"^^xsd:string , "UMLS:C0011900"^^xsd:string , "NCIt:Diagnosis"^^xsd:string , "SNOMEDCT:439401001"^^xsd:string , "LNC:LP72437-4"^^xsd:string .
transmed:TMO_0212 a transmed:TMO_0141 ;
rdfs:label "May 2004 human reference sequence (NCBI Build 35)"@en .
transmed:TMO_0127 a owl:Class ;
rdfs:label "ribonucleotide sequence position"@en ;
rdfs:subClassOf transmed:TMO_0125 ;
dc:description "A ribonucleotide sequence position is an ordinal number which reflects the position of a ribonucleotide in relation to the first ribonucleotide of the same ribonucleic acid (RNA)."@en .
transmed:TMO_0001 a owl:Class ;
rdfs:label "formulated pharmaceutical"@en ;
rdfs:subClassOf transmed:TMO_0063 ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onProperty ro:has_proper_part ;
owl:someValuesFrom transmed:TMO_0071
] ;
dc:description "A formulated pharmaceutical is a chemical substance whose granular parts include an active ingredient, an excipient, and possibly a stability regulator for the active ingredient."@en ;
oboInOwl:hasDbXref "medicare:drugs" , "UMLS:C1705957"^^xsd:string , "sider:drugs" , "NCIt:Pharmaceutical_Formulation"^^xsd:string , "pharmgkb:Drug" , "drugbank:drugs" , "dailymed:drugs" .
transmed:TMO_0199 a owl:DatatypeProperty , owl:FunctionalProperty ;
rdfs:label "HapMap population name abbreviation "@en ;
dc:description "A short acronym identifying a sample population that was examined by the HapMap project."@en .
ro:has_part a owl:ReflexiveProperty ;
rdfs:subPropertyOf ro:located_in .
transmed:TMO_0073 a owl:Class ;
rdfs:label "chemical entity role"@en ;
rdfs:subClassOf snap:Role ;
dc:description "A chemical entity role is a role played by a chemical entity."@en ;
owl:disjointWith obo2:IAO_0000442 , transmed:TMO_0074 , transmed:TMO_0221 , transmed:TMO_0006 .
obo2:IAO_0000405 rdfs:subPropertyOf transmed:TMO_0185 .
transmed:TMO_0169 a owl:Class ;
rdfs:label "date"@en ;
rdfs:subClassOf transmed:TMO_0147 .
transmed:TMO_0043 a owl:Class ;
rdfs:label "adverse drug event"@en ;
rdfs:subClassOf transmed:TMO_0061 ;
obo2:IAO_0000119 "CDISC glossary" ;
dc:description "An adverse drug event is a any untoward medical occurrence in a patient or clinical investigation subject administered a pharmaceutical product and which does not necessarily have a causal relationship with this treatment. An adverse event (AE) can therefore be any unintended sign (including an abnormal laboratory finding), symptom,or disease temporally associated with the use of a medicinal (investigational) product, whether or not related to the medicinal (investigational) product."@en ;
oboInOwl:hasDbXref "MSH:D004362"^^xsd:string , "SNOMEDCT:406644009"^^xsd:string , "sider:side_effects" .
obo2:IAO_0000109 rdfs:subClassOf transmed:TMO_0099 .
transmed:TMO_0224 a owl:ObjectProperty ;
rdfs:label "is described by "@en ;
rdfs:range obo2:IAO_0000030 .
transmed:TMO_0139 a owl:Class ;
rdfs:label "human population"@en ;
rdfs:subClassOf transmed:TMO_0045 ;
dc:description "A collection of humans"@en ;
owl:disjointWith transmed:TMO_0046 , transmed:TMO_0036 .
transmed:TMO_0013 a owl:Class ;
rdfs:label "exclusion criterion for clinical trial"@en ;
rdfs:subClassOf transmed:TMO_0077 ;
dc:description "An exclusion criterion for clinical trial is a clinical trial criterion which, if satisfied, supports the exclusion of candidate patients."@en ;
oboInOwl:hasDbXref "IAO:0000124" .
transmed:TMO_0109 a owl:Class ;
rdfs:label "obsolete"@en .
snap:MaterialEntity a owl:Class .
transmed:TMO_0170 a owl:Class ;
rdfs:label "publication date"@en ;
rdfs:subClassOf transmed:TMO_0169 .
dc:publisher a owl:AnnotationProperty .
ro:part_of a owl:ObjectProperty , owl:ReflexiveProperty ;
rdfs:subPropertyOf ro:location_of .
transmed:TMO_0085 a owl:Class ;
rdfs:label "age"@en ;
rdfs:subClassOf transmed:TMO_0084 ;
dc:description "Age is the temporal quality of an organism that refers to the length of time elapsed since it came into existence. For most animals and humans, age refers to the length of time elapsed since birth."@en .
rdfs:label a owl:AnnotationProperty .
transmed:TMO_0140 a owl:Class ;
rdfs:label "regionally-defined human population"@en ;
rdfs:subClassOf transmed:TMO_0139 ;
dc:description "A collection of humans from a particular region."@en .
transmed:TMO_0055 a owl:Class ;
rdfs:label "health outcome"@en ;
rdfs:subClassOf transmed:TMO_0135 ;
dc:description "A health outcome is a medical measure of health or loss of health."@en ;
oboInOwl:hasDbXref "linkedct:secondary_outcomes" , "IAO:0000121" , "linkedct:primary_outcomes" .
transmed:TMO_0110 a owl:Class ;
rdfs:label "statistical quantity"@en ;
rdfs:subClassOf transmed:TMO_0120 .
transmed:TMO_0025 a owl:Class ;
rdfs:label "institution"@en ;
rdfs:subClassOf transmed:TMO_0164 ;
dc:description "An institution is an entity created by legislation or by practice which acts legally in the same way as a person."@en ;
oboInOwl:hasDbXref "linkedct:agency" , "ACGT:Institution"^^xsd:string , "SNOMEDCT:385437003"^^xsd:string , "BIRNLex:2085"^^xsd:string , "LNC:LP76237-4"^^xsd:string , "UMLS:C1272753"^^xsd:string , "NCIt:Institution"^^xsd:string , "dailymed:organization" .
transmed:TMO_0206 a owl:NamedIndividual , transmed:TMO_0140 ;
rdfs:label "Gujarati Indians in Houston, Texas"@en ;
dc:description "The genetic characteristics of this population were described by the HapMap project and are used as a reference for other genetic studies."@en ;
transmed:TMO_0199 "GIH"^^xsd:string .
transmed:TMO_0182 a owl:Class ;
rdfs:label "centimeter"@en ;
rdfs:subClassOf transmed:TMO_0104 .
transmed:TMO_0097 a owl:Class ;
rdfs:label "historical description"@en ;
rdfs:subClassOf transmed:TMO_0089 .
obo2:IAO_0000303 rdfs:subClassOf obo2:IAO_0000009 .
transmed:TMO_0152 a owl:Class ;
rdfs:label "chromosome"@en ;
rdfs:subClassOf transmed:TMO_0168 ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onProperty ro:has_part ;
owl:someValuesFrom transmed:TMO_0220
] .
transmed:TMO_0067 a owl:Class ;
rdfs:label "protein target"@en ;
rdfs:subClassOf transmed:TMO_0035 ;
owl:equivalentClass [ a owl:Class ;
owl:intersectionOf ( transmed:TMO_0035 [ a owl:Restriction ;
owl:onProperty obo2:OBI_0000316 ;
owl:someValuesFrom transmed:TMO_0072
] )
] .
transmed:TMO_0122 a owl:Class ;
rdfs:label "chromosomal sequence position"@en ;
rdfs:subClassOf transmed:TMO_0126 ;
dc:description "A chromosomal nucleotide sequence position is an ordinal number which reflects the position of a nucleotide in relation to the first nucleotide of the same chromosome."@en .
transmed:TMO_0037 a owl:Class ;
rdfs:label "gene"@en ;
rdfs:subClassOf transmed:TMO_0215 ;
dc:description "A gene is a part of DNA that encodes information about other molecular entities."@en ;
oboInOwl:hasDbXref "Galen:Gene"^^xsd:string , "UMLS:C0017337"^^xsd:string , "diseasome:genes" , "SNOMEDCT:67271001"^^xsd:string , "pharmgkb:Gene" , "MSH:D005796"^^xsd:string , "SO:0000704"^^xsd:string , "FMA:Structural_gene"^^xsd:string , "NCIt:Gene_Object"^^xsd:string , "GRO:Gene"^^xsd:string , "LNC:LP32747-5"^^xsd:string , "NCIt:Gene"^^xsd:string , "PRO:Gene"^^xsd:string , "NDFRT:C242394"^^xsd:string .
transmed:TMO_0218 a owl:Class ;
rdfs:label "companion diagnostic role "@en ;
rdfs:subClassOf transmed:TMO_0221 .
transmed:TMO_0194 a owl:Class ;
rdfs:label "medical descriptor"@en ;
rdfs:subClassOf transmed:TMO_0135 .
transmed:TMO_0007 a owl:Class ;
rdfs:label "prognosis"@en ;
rdfs:subClassOf transmed:TMO_0059 ;
obo2:IAO_0000119 "NCI Thesaurus" ;
dc:description "A prognosis is a hypothesis about the likely course of a disease, the chance of recovery or recurrence."@en ;
oboInOwl:hasDbXref "Galen:Prognosis"^^xsd:string , "MSH:D011379"^^xsd:string , "NCIt:Prognosis"^^xsd:string , "UMLS:C0033325"^^xsd:string .
obo2:IAO_0000400 rdfs:subClassOf transmed:TMO_0116 .
transmed:TMO_0164 a owl:Class ;
rdfs:label "organization"@en ;
rdfs:subClassOf snap:GenericallyDependentContinuant ;
owl:disjointWith obo2:IAO_0000030 .
transmed:TMO_0079 a owl:ObjectProperty ;
rdfs:label "in relation to"@en .
transmed:TMO_0134 a owl:Class ;
rdfs:label "three letter amino acid sequence"@en ;
rdfs:subClassOf transmed:TMO_0129 .
transmed:TMO_0049 a owl:Class ;
rdfs:label "metabolite role"@en ;
rdfs:subClassOf transmed:TMO_0073 ;
dc:description "A metabolite role is the role played by a material entity that is a metabolic substrate, intermediate or product."@en ;
oboInOwl:hasDbXref "UMLS:C0870883"^^xsd:string , "LNC:LP20702-4"^^xsd:string , "NCIt:Metabolite"^^xsd:string , "CHEBI:25212"^^xsd:string , "Galen:Metabolite"^^xsd:string .
transmed:TMO_0104 a owl:Class ;
rdfs:label "unit of measurement"@en ;
rdfs:subClassOf transmed:TMO_0099 .
obo2:IAO_0000442 owl:disjointWith transmed:TMO_0074 , transmed:TMO_0221 , transmed:TMO_0073 , transmed:TMO_0006 .
transmed:TMO_0019 a owl:Class ;
rdfs:label "phenotype"@en ;
rdfs:subClassOf transmed:TMO_0084 ;
dc:description "A phenotype is an observable characteristic of an organism."@en .
transmed:TMO_0080 a owl:Class ;
rdfs:label "genotype"@en ;
rdfs:subClassOf transmed:TMO_0228 ;
dc:description "In this context, a genotype is a material entity made up of two DNA regions on two homologous chromosomes in a diploid cell. One chromosome is derived from the father and one is derived from the mother. The two DNA regions are located at the same genetic locus on each of the two chromosomes."@en .
transmed:TMO_0176 a owl:Class ;
rdfs:label "pharmgkb sample identifier"@en ;
rdfs:subClassOf transmed:TMO_0158 .
transmed:TMO_0050 a owl:Class ;
rdfs:label "drug efficacy"@en ;
rdfs:subClassOf transmed:TMO_0100 ;
dc:description "Drug efficacy is a measure of the capabilty of a drug to produce an intended effect as a function of its concentration."@en ;
oboInOwl:hasDbXref "IAO:0000124" .
transmed:TMO_0146 a owl:Class ;
rdfs:label "physical quantity"@en ;
rdfs:subClassOf transmed:TMO_0099 .
transmed:TMO_0020 a owl:Class ;
rdfs:label "personal medical history"@en ;
rdfs:subClassOf transmed:TMO_0098 ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onProperty obo2:IAO_0000136 ;
owl:someValuesFrom transmed:TMO_0124
] ;
dc:description "A personal medical history is a medical record consisting of a collection of information obtained from the patient and from other sources concerning the patient's health."@en ;
oboInOwl:hasDbXref "NCIt:Personal_Medical_History"^^xsd:string , "UMLS:C0262926"^^xsd:string , "pchr:Encounter" .
transmed:TMO_0201 a owl:NamedIndividual , transmed:TMO_0140 ;
rdfs:label "Han Chinese in Beijing, China"@en ;
dc:description "A population of individuals living in the residential community at Beijing Normal University who were self-identified as having at least three out of four Han Chinese grandparents. Although individuals of Beijing Normal University were from many different parts of China, this set of samples was not drawn to be representative of all Han Chinese people. The genetic characteristics of this population were described by the HapMap project and are used as a reference for other genetic studies."@en ;
transmed:TMO_0199 "CHB"^^xsd:string .
transmed:TMO_0116 a owl:Class ;
rdfs:label "spatial positional datum"@en ;
rdfs:subClassOf transmed:TMO_0137 .
transmed:TMO_0092 a owl:Class ;
rdfs:label "comparative description"@en ;
rdfs:subClassOf transmed:TMO_0089 .
snap:GenericallyDependentContinuant
a owl:Class .
transmed:TMO_0188 a owl:Class ;
rdfs:label "mass per unit time"@en ;
rdfs:subClassOf transmed:TMO_0104 .
transmed:TMO_0062 a owl:Class ;
rdfs:label "pharmaceutical ingredient role"@en ;
rdfs:subClassOf transmed:TMO_0073 ;
dc:description "A pharmaceutical ingredient role is a role played by a chemical substance that is part of a pharmaceutical formulation."@en .
transmed:TMO_0158 a owl:Class ;
rdfs:label "item in collection identifier"@en ;
rdfs:subClassOf transmed:TMO_0137 ;
dc:description "An item in a collection identifier is an identifier for an entity that is a member of a collection."@en .
dc:rights a owl:AnnotationProperty .
transmed:TMO_0032 a owl:Class ;
rdfs:label "clinical trial"@en ;
rdfs:subClassOf transmed:TMO_0029 ;
dc:description "A clinical trial is a study to assess the efficacy of a substance for the treatment of a condition."@en ;
oboInOwl:hasDbXref "HL7V3.0:CLNTRL"^^xsd:string , "IAO:0000121" , "SNOMEDCT:110465008"^^xsd:string , "MSH:D016430"^^xsd:string , "NCIt:Clinical_Trial"^^xsd:string , "linkedct:trials" .
transmed:TMO_0213 a transmed:TMO_0141 ;
rdfs:label "March 2006 human reference sequence (NCBI Build 36.1)"@en .
transmed:TMO_0128 a owl:Class ;
rdfs:label "sequence"@en ;
rdfs:subClassOf transmed:TMO_0089 ;
dc:description "A sequence is an ordered list of objects of a specified type."@en .
transmed:TMO_0002 a owl:Class ;
rdfs:label "pharmaceutical product"@en ;
rdfs:subClassOf transmed:TMO_0001 ;
dc:description "A pharmaceutical product is a formulated pharmaceutical that has been approved to treat patients."@en ;
oboInOwl:hasDbXref "NCIt:Finished_Pharmaceutical_Product"^^xsd:string , "UMLS:C1708062"^^xsd:string .
obo2:IAO_0000310 a owl:Class ;
oboInOwl:hasDbXref "drugbank:references" .
transmed:TMO_0074 a owl:Class ;
rdfs:label "expert role"@en ;
rdfs:subClassOf snap:Role ;
dc:description "An expert role is a role played by a knowledgeable person."@en ;
owl:disjointWith obo2:IAO_0000442 , transmed:TMO_0221 , transmed:TMO_0073 , transmed:TMO_0006 .
obo2:IAO_0000406 rdfs:subPropertyOf transmed:TMO_0185 .
transmed:TMO_0044 a owl:Class ;
rdfs:label "pathway"@en ;
rdfs:subClassOf transmed:TMO_0090 ;
obo2:IAO_0000119 "NCI Thesaurus" ;
dc:description "A pathway is a representation of a set or series of interactions, often forming a network, which biologists have found useful to group together for organizational, historic, biophysical, or other reasons."@en ;
oboInOwl:hasDbXref "IEV:0000001"^^xsd:string , "NCIt:Pathway"^^xsd:string , "GRO:Pathway"^^xsd:string , "Galen:Pathway"^^xsd:string , "MI:0619"^^xsd:string .
transmed:TMO_0225 a owl:Class ;
rdfs:label "genotype with indel variation"@en ;
rdfs:subClassOf transmed:TMO_0080 ;
dc:description "A genotype of which variants exist that differ though an insertion, deletion or a combination thereof."@en .
transmed:TMO_0014 a owl:Class ;
rdfs:label "inclusion criterion for clinical trial"@en ;
rdfs:subClassOf transmed:TMO_0077 ;
dc:description "A inclusion criterion for clinical trial is a clinical trial criterion which, if satisfied, supports the inclusion of candidate patients."@en ;
oboInOwl:hasDbXref "IAO:0000124" .
transmed:TMO_0171 a owl:Class ;
rdfs:label "gene name"@en ;
rdfs:subClassOf obo2:IAO_0000009 .
transmed:TMO_0086 a owl:Class ;
rdfs:label "sex"@en ;
rdfs:subClassOf transmed:TMO_0084 ;
dc:description "Sex is an quality that inheres in an organism for which sexual differentiation is required for sexual reproduction."@en .
transmed:TMO_0141 a owl:Class ;
rdfs:label "reference genomic sequence"@en ;
rdfs:subClassOf transmed:TMO_0138 ;
dc:description "A reference genomic sequence is a genomic sequence that serves as a standard or reference, and may be composed by the consensus of the genomes of a number of individuals or parts thereof."@en .
transmed:TMO_0056 a owl:Class ;
rdfs:label "toxicity"@en ;
rdfs:subClassOf snap:Quality ;
dc:description "Toxicity is a quality of a chemical substance which indicates the capacity to cause injury to an organism in a dose dependent manner."@en ;
oboInOwl:hasDbXref "ACGT:Toxicity"^^xsd:string , "MSH:Q000633"^^xsd:string , "NCIt:Toxicity"^^xsd:string , "UMLS:C0600688"^^xsd:string .
dc:subject a owl:AnnotationProperty .
transmed:TMO_0111 a owl:Class ;
rdfs:label "p-value"@en ;
rdfs:subClassOf transmed:TMO_0110 .
transmed:TMO_0026 a owl:Class ;
rdfs:label "regulatory authority"@en ;
rdfs:subClassOf transmed:TMO_0025 ;
dc:description "A regulatory authority is an institution created by legislation which acts to control what treatments can be prescribed."@en .
transmed:TMO_0207 a owl:NamedIndividual , transmed:TMO_0140 ;
rdfs:label "Luhya in Webuye, Kenya"@en ;
dc:description "The genetic characteristics of this population were described by the HapMap project and are used as a reference for other genetic studies."@en ;
transmed:TMO_0199 "LWK"^^xsd:string .
transmed:TMO_0183 a owl:Class ;
rdfs:label "kilogram"@en ;
rdfs:subClassOf transmed:TMO_0104 .
transmed:TMO_0098 a owl:Class ;
rdfs:label "medical history"@en ;
rdfs:subClassOf transmed:TMO_0097 .
transmed:TMO_0153 a owl:Class ;
rdfs:label "nucleotide residue"@en ;
rdfs:subClassOf transmed:TMO_0109 .
transmed:TMO_0068 a owl:Class ;
rdfs:label "diagnostic criterion"@en ;
rdfs:subClassOf transmed:TMO_0151 ;
dc:description "A diagnostic criterion is a directive information entity for consideration during a diagnosis which, if satisfied, contributes to a diagnostic result"@en ;
oboInOwl:hasDbXref "IAO:0000124" .
transmed:TMO_0123 a owl:Class ;
rdfs:label "amino acid sequence position"@en ;
rdfs:subClassOf transmed:TMO_0119 ;
dc:description "An amino acid sequence position indicates the position of an amino acid residue in relation to the start of the peptide chain."@en .
transmed:TMO_0038 a owl:Class ;
rdfs:label "genotype with SNP"@en ;
rdfs:subClassOf transmed:TMO_0080 ;
dc:description "A genotype with a single-nucleotide polymorphism (SNP). A SNP is a variation at a single nucleotide locus in the genomes of members of a species. For a variation to be considered a SNP, it must occur in at least 1% of the population."@en ;
oboInOwl:hasDbXref "MSH:D020641"^^xsd:string , "NCIt:Single_Nucleotide_Polymorphism"^^xsd:string , "SO:0000694"^^xsd:string , "UMLS:C0752046"^^xsd:string .
transmed:TMO_0304 a owl:Class ;
rdfs:label "drug interaction"@en ;
rdfs:subClassOf span:ProcessualEntity ;
dc:description "A drug interaction is a process in which a drug interacts with a living system in such a way that it affects its behaviour."@en ;
oboInOwl:hasDbXref "drugbank:drug_interactions" , "pharmgkb:DrugGeneVariantInteraction" , "pharmgkb:Association" .
transmed:TMO_0219 a owl:Class ;
rdfs:label "genetic test"@en ;
rdfs:subClassOf transmed:TMO_0076 .
transmed:TMO_0008 a owl:Class ;
rdfs:label "patient role"@en ;
rdfs:subClassOf transmed:TMO_0060 ;
dc:description "A patient role is a role played a human subject that receives medical attention, care or treatment or who is registered with a medical institution with the purpose of receiving medical care when necessary."@en .
transmed:TMO_0195 a owl:Class ;
rdfs:label "smoker status"@en ;
rdfs:subClassOf transmed:TMO_0194 ;
dc:description "Smoker status is a medical descriptor of the tobacco smoking behaviour of a person."@en .
transmed:TMO_0165 a owl:Class ;
rdfs:label "gene symbol"@en ;
rdfs:subClassOf obo2:IAO_0000028 .
transmed:TMO_0220 a owl:Class ;
rdfs:label "DNA"@en ;
rdfs:subClassOf transmed:TMO_0034 ;
owl:disjointWith transmed:TMO_0168 , transmed:TMO_0035 .
transmed:TMO_0135 a owl:Class ;
rdfs:label "medical description"@en ;
rdfs:subClassOf transmed:TMO_0089 .
transmed:TMO_0105 a owl:Class ;
rdfs:label "multitude numerical quantity"@en ;
rdfs:subClassOf transmed:TMO_0121 ;
dc:description "A multitude numerical quantity is a numerical quantity that indicates the number of individuals."@en .
transmed:TMO_0081 a owl:Class ;
rdfs:label "haplotype"@en ;
rdfs:subClassOf transmed:TMO_0172 ;
dc:description "A haplotype a variant DNA region which contains several smaller variant DNA regions which tend to be inherited together."@en .
transmed:TMO_0051 a owl:Class ;
rdfs:label "treatment safety value"@en ;
rdfs:subClassOf transmed:TMO_0100 ;
obo2:IAO_0000119 "NCI Thesaurus" ;
dc:description "Treatment safety is a condition that refers to an absence of harmful side effects resulting from use of the product and may be assessed by laboratory testing of biological samples, special tests and procedures, psychiatric evaluation, and/or physical examination of subjects."@en ;
oboInOwl:hasDbXref "IAO:0000124" .
transmed:TMO_0147 a owl:Class ;
rdfs:label "temporal quantity"@en ;
rdfs:subClassOf transmed:TMO_0146 .
transmed:TMO_0021 a owl:Class ;
rdfs:label "clinical trial protocol"@en ;
rdfs:subClassOf transmed:TMO_0016 ;
dc:description "A clinical trial protocol is a clinical protocol about the objective(s), design, methodology, statistical considerations, and organization of a clinical trial."@en .
transmed:TMO_0202 a owl:NamedIndividual , transmed:TMO_0140 ;
rdfs:label "Japanese in Tokyo, Japan"@en ;
dc:description "A population in the Tokyo metropolitan area, with people who came from (or whose ancestors came from) many different parts of Japan. Thus, this population can be viewed as representative of the majority population in Japan. The genetic characteristics of this population were described by the HapMap project and are used as a reference for other genetic studies."@en ;
transmed:TMO_0199 "JPT"^^xsd:string .
transmed:TMO_0117 a owl:Class ;
rdfs:label "magnitude of a genetic marker"@en ;
rdfs:subClassOf transmed:TMO_0102 ;
dc:description "A magnitude of a genetic marker refers to the the significance of some genetic marker"@en .
transmed:TMO_0093 a owl:Class ;
rdfs:label "measure"@en ;
rdfs:subClassOf transmed:TMO_0109 ;
dc:description "A measure is an information content entity that describes or quantifies some thing."@en .
obo2:IAO_0000033 a owl:Class ;
rdfs:subClassOf transmed:TMO_0089 .
snap:Continuant a owl:Class ;
oboInOwl:hasDbXref "dcterms:Agent" , "foaf:Agent" , "dcterms:AgentClass" .
transmed:TMO_0189 a owl:Class ;
rdfs:label "milligram per week"@en ;
rdfs:subClassOf transmed:TMO_0188 .
transmed:TMO_0063 a owl:Class ;
rdfs:label "chemical substance"@en ;
rdfs:subClassOf snap:MaterialEntity ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onProperty ro:has_proper_part ;
owl:someValuesFrom transmed:TMO_0034
] ;
dc:description "A chemical substance is a material entity consisting of many chemical entities and typically has connected boundaries."@en .
transmed:TMO_0159 a owl:Class ;
rdfs:label "item in sequence identifier"@en ;
rdfs:subClassOf transmed:TMO_0158 ;
dc:description "An item in a collection identifier is an identifier for an entity that is a member of an ordered sequence of items (based on some attribute)."@en .
transmed:TMO_0033 a owl:Class ;
rdfs:label "drug measure"@en ;
rdfs:subClassOf transmed:TMO_0010 ;
dc:description "A drug measure is a biomedical measure that describes or is a measure of drugs or their activies."@en .
transmed:TMO_0214 a transmed:TMO_0141 ;
rdfs:label "February 2009 human reference sequence (GRCh37)"@en .
transmed:TMO_0129 a owl:Class ;
rdfs:label "amino acid sequence"@en , "protein sequence"@en ;
rdfs:subClassOf transmed:TMO_0128 ;
dc:description "An amino acid sequence is a sequence of amino acids in which a word (1 more more sequence of characters) represents an amino acid and their adjacency indicates their connectivity."@en ;
owl:disjointWith transmed:TMO_0130 .
transmed:TMO_0003 a owl:Class ;
rdfs:label "inactive ingredient"@en ;
rdfs:subClassOf transmed:TMO_0071 ;
dc:description "An inactive ingredient is a pharmaceutical ingredient that is part of a pharmaceutical formulation but does not have the disposition to treat a certain disease."@en ;
oboInOwl:hasDbXref "HL7V3.0:IACT"^^xsd:string ;
owl:equivalentClass [ a owl:Class ;
owl:intersectionOf ( transmed:TMO_0071 [ a owl:Restriction ;
owl:onProperty obo2:OBI_0000316 ;
owl:someValuesFrom transmed:TMO_0065
] [ a owl:Restriction ;
owl:onProperty ro:part_of ;
owl:someValuesFrom transmed:TMO_0001
] )
] .
transmed:TMO_0190 a owl:Class ;
rdfs:label "dose"@en ;
rdfs:subClassOf transmed:TMO_0113 .
transmed:TMO_0075 a owl:Class ;
rdfs:label "planned process"@en ;
rdfs:subClassOf span:ProcessualEntity ;
dc:description "A planned process is a process in which specific objectives are realized in a plan designed by some agent."@en ;
oboInOwl:hasDbXref "BIRNLex:11021"^^xsd:string , "OBI:0000011"^^xsd:string .
obo2:OBI_0000316 a owl:ObjectProperty ;
rdfs:label "has role"@en ;
rdfs:subPropertyOf transmed:TMO_0196 .
transmed:TMO_0130 a owl:Class ;
rdfs:label "nucleotide sequence"@en ;
rdfs:subClassOf transmed:TMO_0128 ;
dc:description "A nucleotide sequence is a sequence of nucleotides in which a word (1 more more sequence of characters) represents a nucleotide and their adjacency indicates their connectivity."@en .
transmed:TMO_0045 a owl:Class ;
rdfs:label "population"@en ;
rdfs:subClassOf snap:MaterialEntity ;
dc:description "A population is a collection of organisms."@en ;
oboInOwl:hasDbXref "OCRe_research:Population" , "dcterms:AgentClass" , "IAO:0000120" .
dc:description a owl:AnnotationProperty .
transmed:TMO_0226 a owl:Class ;
rdfs:label "genotype with short tandem repeat variation"@en ;
rdfs:subClassOf transmed:TMO_0080 .
transmed:TMO_0100 a owl:Class ;
rdfs:label "functional quantity"@en ;
rdfs:subClassOf transmed:TMO_0120 ;
dc:description "A functional quantity is a quantity obtained as a result of a function involving one or more parameters."@en .
transmed:TMO_0015 a owl:Class ;
rdfs:label "diagnostic result"@en ;
rdfs:subClassOf transmed:TMO_0136 ;
dc:description "A diagnostic result is a medical measure of determining the nature of a problem or illness through medical procedure."@en ;
oboInOwl:hasDbXref "IAO:0000124" .
transmed:TMO_0172 a owl:Class ;
rdfs:comment "A variant DNA region is a DNA region of which variants with altered sequence exist in different individuals of the same species or in different samples of the same individual (e.g., genetic variation within an individual, such as mutations in a cancerous tumor). The number of nucleotide residues in different variants can differ (e.g., because of insertions and deletions)."^^xsd:string ;
rdfs:label "variant DNA region"@en ;
rdfs:subClassOf transmed:TMO_0215 ;
rdfs:subClassOf [ a owl:Restriction ;
owl:onProperty transmed:TMO_0216 ;
owl:someValuesFrom transmed:TMO_0215
] ;
owl:equivalentClass [ a owl:Class ;
owl:intersectionOf ( [ a owl:Restriction ;
owl:onProperty transmed:TMO_0216 ;
owl:someValuesFrom transmed:TMO_0215
] transmed:TMO_0215 )
] .
transmed:TMO_0087 a owl:Class ;
rdfs:label "male"@en ;
rdfs:subClassOf transmed:TMO_0086 ;
dc:description "Male is a sex quality for which sex organs contain only male gametes"@en ;
owl:disjointWith transmed:TMO_0088 .
transmed:TMO_0142 a owl:Class ;
rdfs:label "medical report"@en ;
rdfs:subClassOf transmed:TMO_0135 .
transmed:TMO_0057 a owl:Class ;
rdfs:label "dosage"@en ;
rdfs:subClassOf transmed:TMO_0113 ;
dc:description "Dosage is the amount of a chemical administered to, or taken by, an organism and expressed as some function of the organism and of time (mg/kg body weight/day)."@en ;
oboInOwl:hasDbXref "UMLS:C0178602"^^xsd:string , "LNC:LP6801-7"^^xsd:string , "SNOMEDCT:260911001"^^xsd:string , "EFO:0000428"^^xsd:string , "NCIt:Dose"^^xsd:string .
transmed:TMO_0112 a owl:Class ;
rdfs:label "e-value"@en ;
rdfs:subClassOf transmed:TMO_0110 .
transmed:TMO_0027 a owl:Class ;
rdfs:comment "This is, at the moment, a kind of institution because \nthe payers are typically insurance companies or government bodies.\nBut it is possible in some jurisdictions to pay for treatment oneself.\nTreat by renaming to \"institutional payer\". --CRB" ;
rdfs:label "institutional payer"@en ;
rdfs:subClassOf transmed:TMO_0025 ;
oboInOwl:hasDbXref "NCIt:Healthcare_Payer"^^xsd:string , "UMLS:C2348942"^^xsd:string .
transmed:TMO_0208 a owl:NamedIndividual , transmed:TMO_0140 ;
rdfs:label "Population with mexican ancestry in Los Angeles, California"@en ;
dc:description "The genetic characteristics of this population were described by the HapMap project and are used as a reference for other genetic studies."@en ;
transmed:TMO_0199 "MXL"^^xsd:string .
transmed:TMO_0184 a owl:Class ;
rdfs:label "year"@en ;
rdfs:subClassOf transmed:TMO_0104 .
transmed:TMO_0099 a owl:Class ;
rdfs:label "numerical quantity"@en ;
rdfs:subClassOf transmed:TMO_0094 .
transmed:TMO_0154 a owl:Class ;
rdfs:label "amino acid residue"@en ;
rdfs:subClassOf transmed:TMO_0109 .
snap:Quality a owl:Class .
transmed:TMO_0069 a owl:Class ;
rdfs:label "diagnostic inclusion criterion"@en ;
rdfs:subClassOf transmed:TMO_0068 ;
dc:description "A diagnostic inclusion criterion is a diagnostic criterion for consideration during a diagnosis which, if satisfied, supports a diagnostic result."@en ;
oboInOwl:hasDbXref "IAO:0000124" .
obo2:IAO_0000009 rdfs:subClassOf transmed:TMO_0137 .